Multi-scale mechanobiological model for skeletal muscle hypertrophy.

ABSTRACT: Skeletal muscle adaptation is correlated to training exercise by triggering different signaling pathways that target many functions; in particular, the IGF1-AKT pathway controls protein synthesis and degradation. These two functions regulate the adaptation in size and strength of muscles. Computational models for muscle adaptation have focused on: the biochemical description of signaling pathways or the mechanical description of muscle function at organ scale; however, an interrelation between these two models should be considered to understand how an adaptation in muscle size affects the protein synthesis rate. In this research, a dynamical model for the IGF1-AKT signaling pathway is linked to a continuum-mechanical model describing the active and passive mechanical response of a muscle;

SUBMITTER: Villota-Narvaez Y 

PROVIDER: S-EPMC9582841 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature