Dataset Information

Muscle mass and physical function in patients with bladder cancer-Data from a prematurely terminated prospective cohort study.

ABSTRACT:

Background

Patients with bladder cancer (BC) have a high prevalence of comorbidity and low adherence to systemic anticancer treatment but it is unknown whether this is associated with sarcopenia.

Objective

We aimed to investigate if the sarcopenia-defining parameters (muscle strength, muscle mass and physical performance) were associated with reduced adherence to systemic anticancer treatment in patients with BC, and if these muscle domains changed during treatment.

Methods

Patients >18 years of age with BC referred for chemotherapy or immunotherapy at Department of Oncology, Rigshospitalet, Denmark were eligible for study inclusion. Measurements were performed before treatment initiation and within one week after treatment termination, and consisted of assessments of muscle strength, muscle mass, and physical performance. Data was compared with thresholds outlined by the European Working Group on Sarcopenia in Older Patient's (EWGSOP2) guidelines and a healthy, age-matched Danish cohort.

Results

Over a period of 29 months, we included 14 patients of whom two completed follow-up measurements. The recruitment rate was <50% of planned due to logistics and Covid-19 related limitations. Consequently, a decision to prematurely terminate the study was made. No patients fulfilled EWGSOP2 criteria for sarcopenia, but the majority had reduction in one or more muscle domains compared to healthy, age-matched individuals. The majority of patients had poor treatment tolerance, leading to dose reductions and postponed treatments.

Conclusions

In this prematurely terminated study, no patients fulfilled EWGSOP2 criteria for sarcopenia, yet, most patients were affected in one or more muscle domains and the majority had compromised treatment adherence.

SUBMITTER: Omland LH

PROVIDER: S-EPMC9582947 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Muscle mass and physical function in patients with bladder cancer-Data from a prematurely terminated prospective cohort study.

Omland Lise Høj LH Ammitzbøll Gunn G Lund Cecilia Margareta CM Lindberg Henriette H Dalton Susanne Oksbjerg SO Suetta Charlotte C Pappot Helle H

Frontiers in rehabilitation sciences 20221006

<h4>Background</h4>Patients with bladder cancer (BC) have a high prevalence of comorbidity and low adherence to systemic anticancer treatment but it is unknown whether this is associated with sarcopenia.<h4>Objective</h4>We aimed to investigate if the sarcopenia-defining parameters (muscle strength, muscle mass and physical performance) were associated with reduced adherence to systemic anticancer treatment in patients with BC, and if these muscle domains changed during treatment.<h4>Methods</h4 ...[more]

PMID: 36275921

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Dataset Information

Muscle mass and physical function in patients with bladder cancer-Data from a prematurely terminated prospective cohort study.

Background

Objective

Methods

Results

Conclusions

Publications

Muscle mass and physical function in patients with bladder cancer-Data from a prematurely terminated prospective cohort study.

Similar Datasets

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