Synthesis and Characterization of Derivatives of the Antifungal Peptoid RMG8-8.

ABSTRACT: Cryptococcal meningitis, caused by the fungal pathogen Cryptococcus neoformans, is a devastating disease with a mortality rate of over 80%. Due to the increasing prevalence of resistance to antifungals and the high mammalian toxicity of current treatments, the development of new antifungal therapies is vital. In an effort to improve the biological properties of a previously discovered antifungal peptoid, termed RMG8-8, an iterative structure-activity relationship study was conducted. This three-round study sought to optimize the structure of RMG8-8 by focusing on three main structural components: the lipophilic tail, aliphatic side chains, and aromatic side chains. In addition to antifungal testing against C. neoformans, cytotoxicity testing was also performed on all derivati

SUBMITTER: Pratt EJ 

PROVIDER: S-EPMC9583092 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature