Bacteroides abundance drives birth mode dependent infant gut microbiota developmental trajectories.

ABSTRACT:

Background and aims

Birth mode and other early life factors affect a newborn's microbial colonization with potential long-term health effects. Individual variations in early life gut microbiota development, especially their effects on the functional repertoire of microbiota, are still poorly characterized. This study aims to provide new insights into the gut microbiome developmental trajectories during the first year of life.

Methods

Our study comprised 78 term infants sampled at 3 weeks, 3 months, 6 months, and 12 months (n = 280 total samples), and their mothers were sampled in late pregnancy (n = 50). Fecal DNA was subjected to shotgun metagenomic sequencing. Infant samples were studied for taxonomic and functional maturation, and maternal microbiota was use

SUBMITTER: Matharu D 

PROVIDER: S-EPMC9583133 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature