Development and validation of a nomogram based on lymphocyte subsets to distinguish bipolar depression from major depressive disorder.

ABSTRACT:

Objective

Bipolar depression (BD) and major depressive disorder (MDD) are both common affective disorders. The common depression episodes make it difficult to distinguish between them, even for experienced clinicians. Failure to properly diagnose them in a timely manner leads to inappropriate treatment strategies. Therefore, it is important to distinguish between BD and MDD. The aim of this study was to develop and validate a nomogram model that distinguishes BD from MDD based on the characteristics of lymphocyte subsets.

Materials and methods

A prospective cross-sectional study was performed. Blood samples were obtained from participants who met the inclusion criteria. The least absolute shrinkage and selection operator (LASSO) regression model was used for factor selection

SUBMITTER: Su L 

PROVIDER: S-EPMC9583168 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature