The Sympathetic Nervous System Modulates Cancer Vaccine Activity through Monocyte-Derived Cells.

ABSTRACT: The sympathetic nervous system (SNS) is an important regulator of immune cell function during homeostasis and states of inflammation. Recently, the SNS has been found to bolster tumor growth and impair the development of antitumor immunity. However, it is unclear whether the SNS can modulate APC function. Here, we investigated the effects of SNS signaling in murine monocyte-derived macrophages (moMФ) and dendritic cells (DCs) and further combined the nonspecific β-blocker propranolol with a peptide cancer vaccine for the treatment of melanoma in mice. We report that norepinephrine treatment dramatically altered moMФ cytokine production, whereas DCs were unresponsive to norepinephrine and critically lack β₂-adrenergic receptor expression. In addition, we show that propranolol plu

SUBMITTER: Hinkle L 

PROVIDER: S-EPMC9583274 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature