Retinal nerve fiber layer in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

ABSTRACT:

Purpose

Tauopathy and transactive response DNA binding protein 43 (TDP-43) proteinopathy are associated with neurodegenerative diseases. These proteinopathies are difficult to detect in vivo. This study examined if spectral-domain optical coherence tomography (SD-OCT) can differentiate in vivo the difference in peripapillary retinal nerve fibre layer (pRNFL) thickness and macular retinal thickness between participants with presumed tauopathy (progressive supranuclear palsy) and those with presumed TDP-43 proteinopathy (amyotrophic lateral sclerosis and semantic variant primary progressive aphasia).

Study design

Prospective, multi-centre, observational study.

Materials and methods

pRNFL and macular SD-OCT images were acquired in both eyes of each particip

SUBMITTER: Wong BM 

PROVIDER: S-EPMC9583385 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature