Biological variation and reference change value of the estimated glomerular filtration rate in humans: A systematic review and meta-analysis.

ABSTRACT:

Background

Knowledge of the biological variation of serum or plasma creatinine (Cr) and the estimated glomerular filtration rate (eGFR) is important for understanding disease dynamics in Chronic Kidney Disease (CKD). The aim of our study was to determine the magnitude of random fluctuation of eGFR by determining its reference change value (RCV).

Methods

We performed a systematic review and meta-analysis of studies on biological variation of Cr. Relevant studies were identified by systematic literature search on PubMed. Additional studies were retrieved from the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Biological Variation Database. Random-effects meta-analysis was conducted to derive an overall estimate of intra-individual variation of creatin

SUBMITTER: Thoni S 

PROVIDER: S-EPMC9583397 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature