Study on the prognosis, immune and drug resistance of m6A-related genes in lung cancer.

ABSTRACT:

Background

Few studies have demonstrated that the relationship between m6A-related genes and the prognosis, tumor microenvironment and drug resistance of LC.

Methods

The main results were analyzed with bioinformatics methods.

Results

Hence, we found 10 m6A-related genes expressed less in tumor samples in comparison with normal ones. Using consensus clustering, all LC patients were grouped into 2 subgroups according to the overall expression of 10 differential expressed m6A-related genes. In two clusters, the OS and immune characteristics were different. We analyzed the predictive potential of 10 m6A-related genes in the prognosis of LC, and obtained a risk prognosis model on the strength of ZC3H13, CBLL1, ELAVL1 and YTHDF1 as the hub candidate genes through LASSO cox.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9583491 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature