HP1a-mediated heterochromatin formation promotes antimicrobial responses against Pseudomonas aeruginosa infection.

ABSTRACT:

Background

Pseudomonas aeruginosa is a Gram-negative bacterium that causes severe infectious disease in diverse host organisms, including humans. Effective therapeutic options for P. aeruginosa infection are limited due to increasing multidrug resistance and it is therefore critical to understand the regulation of host innate immune responses to guide development of effective therapeutic options. The epigenetic mechanisms by which hosts regulate their antimicrobial responses against P. aeruginosa infection remain unclear. Here, we used Drosophila melanogaster to investigate the role of heterochromatin protein 1a (HP1a), a key epigenetic regulator, and its mediation of heterochromatin formation in antimicrobial responses against PA14, a highly virulent P. aeruginosa strain.

Resul

SUBMITTER: Wu PJ 

PROVIDER: S-EPMC9583553 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature