A map of cis-regulatory modules and constituent transcription factor binding sites in 80% of the mouse genome.

ABSTRACT:

Background

Mouse is probably the most important model organism to study mammal biology and human diseases. A better understanding of the mouse genome will help understand the human genome, biology and diseases. However, despite the recent progress, the characterization of the regulatory sequences in the mouse genome is still far from complete, limiting its use to understand the regulatory sequences in the human genome.

Results

Here, by integrating binding peaks in ~ 9,000 transcription factor (TF) ChIP-seq datasets that cover 79.9% of the mouse mappable genome using an efficient pipeline, we were able to partition these binding peak-covered genome regions into a cis-regulatory module (CRM) candidate (CRMC) set and a non-CRMC set. The CRMCs contain 912,197 putative CRMs and 3

SUBMITTER: Ni P 

PROVIDER: S-EPMC9583556 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature