Examples Showing the Utility of Doping Experiments in ¹H NMR Analysis of Mixtures.

ABSTRACT: Here we provide examples that demonstrate the value of using properly designed and easily performed doping experiments to give insights about the nature of the analyte(s) present in a ¹H NMR sample. Two mixtures, the first quite complex and the second far less so, have been chosen: (i) the crude pyrolysate from reaction of butyric acid in (supercritical) water at 600 °C and (ii) a mixture of two basic amines. In the former, 13 distinct carbonyl-containing compounds, ranging in relative concentration of nearly 2 orders of magnitude, were positively identified. The latter highlights the advantage of using a doping experiment as opposed to merely comparing the spectra from two separate samples containing the same analyte.

SUBMITTER: Kaicharla T 

PROVIDER: S-EPMC9583569 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature