Causality of genetically determined metabolites on anxiety disorders: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Although anxiety disorders are one of the most prevalent mental disorders, their underlying biological mechanisms have not yet been fully elucidated. In recent years, genetically determined metabolites (GDMs) have been used to reveal the biological mechanisms of mental disorders. However, this strategy has not been applied to anxiety disorders. Herein, we explored the causality of GDMs on anxiety disorders through Mendelian randomization study, with the overarching goal of unraveling the biological mechanisms.

Methods

A two-sample Mendelian randomization (MR) analysis was implemented to assess the causality of GDMs on anxiety disorders. A genome-wide association study (GWAS) of 486 metabolites was used as the exposure, whereas four different GWAS datasets of anxie

SUBMITTER: Xiao G 

PROVIDER: S-EPMC9583573 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature