The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

ABSTRACT:

Background

Mycobacteroides abscessus complex (MABC), an emerging pathogen, causes human infections resistant to multiple antibiotics. In this study, the genome data of 1,581 MABC strains were downloaded from NCBI database for phylogenetic relatedness inference, resistance profile identification and the estimation of evolutionary pressure on resistance genes in silico.

Results

From genes associated with resistance to 28 antibiotic classes, 395 putative proteins (ARPs) were identified, based on the information in two antibiotic resistance databases (CARD and ARG-ANNOT). The ARPs most frequently identified in MABC were those associated with resistance to multiple antibiotic classes, beta-lactams and aminoglycosides. After excluding ARPs that had undergone recombination, two ARP

SUBMITTER: Chong SL 

PROVIDER: S-EPMC9583574 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature