Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Various cancer stem cell (CSC) biomarkers and the genes encoding them in head and neck squamous cell carcinoma (HNSCC) have been identified and evaluated. However, the validity of these factors in the prognosis of HNSCC has been questioned and remains unclear. In this study, we examined the clinical significance of CSC biomarker genes in HNSCC, using five publicly available HNSCC cohorts.

Methods

To predict the prognosis of patients with HNSCC, we developed and validated the expression signatures of CSC biomarker genes whose mRNA expression levels correlated with at least one of the four CSC genes (CD44, MET, ALDH1A1, and BMI1).

Results

Patients in The Cancer Genome Atlas (TCGA) HNSCC cohort were classified into CSC gene expression-associated high-risk (CSC

SUBMITTER: Kim SI 

PROVIDER: S-EPMC9583594 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature