Dataset Information

Systematic pattern analyses of Vδ2⁺ TCRs reveal that shared "public" Vδ2⁺ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status.

ABSTRACT:

Background

Vγ9Vδ2⁺ T cells are a major innate T cell subset in human peripheral blood. Their Vδ2⁺ VDJ-rearrangements are short and simple in the fetal thymus and gradually increase in diversity and CDR3 length along with development. So-called "public" versions of Vδ2⁺ TCRs are shared among individuals of all ages. However, it is unclear whether such frequently occurring "public" Vγ9Vδ2⁺ T cell clones are derived from the fetal thymus and whether they are fitter to proliferate and persist than infrequent "private" clones.

Methods

Shared "public" Vδ2⁺ TCRs were identified from Vδ2⁺ TCR-repertoires collected from 89 individuals, including newborns (cord blood), infants, and adults (peripheral blood). Distance ma

SUBMITTER: Deng L

PROVIDER: S-EPMC9583675 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Dataset Information

Systematic pattern analyses of Vδ2⁺ TCRs reveal that shared "public" Vδ2⁺ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status.

Background

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Systematic pattern analyses of Vδ2+ TCRs reveal that shared "public" Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status.

Background

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Systematic pattern analyses of Vδ2⁺ TCRs reveal that shared "public" Vδ2⁺ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status.