Wireless Force-Inducing Neuronal Stimulation Mediated by High Magnetic Moment Microdiscs.

ABSTRACT: Noninvasive manipulation of cell signaling is critical in basic neuroscience research and in developing therapies for neurological disorders and psychiatric conditions. Here, the wireless force-induced stimulation of primary neuronal circuits through mechanotransduction mediated by magnetic microdiscs (MMDs) under applied low-intensity and low-frequency alternating magnetic fields (AMFs), is described. MMDs are fabricated by top-down lithography techniques that allow for cost-effective mass production of biocompatible MMDs with high saturation and zero magnetic magnetic moment at remanence. MMDs are utilized as transducers of AMFs into mechanical forces. When MMDs are exposed to primary rat neuronal circuits, their magneto-mechanical actuation triggers the response of specific mechanosensi

SUBMITTER: Collier C 

PROVIDER: S-EPMC9583708 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature