Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats-A systematic review.

ABSTRACT: Several studies suggested an informative value of behavioral and grimace scale parameters for the detection of pain. However, the robustness and reliability of the parameters as well as the current extent of implementation are still largely unknown. In this study, we aimed to systematically analyze the current evidence-base of grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats. The following platforms were searched for relevant articles: PubMed, Embase via Ovid, and Web of Science. Only full peer-reviewed studies that describe the grimace scale, burrowing, and/or nest building as pain parameters in the post-surgical phase in mice and/or rats were included. Information about the study design, animal characteristics, intervention char

SUBMITTER: Aulehner K 

PROVIDER: S-EPMC9583882 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature