Monocyte-derived peritoneal macrophages protect C57BL/6 mice against surgery-induced adhesions.

ABSTRACT: Peritoneal adhesions commonly occur after abdominal or pelvic surgery. These scars join internal organs to each other or to the cavity wall and can present with abdominal or pelvic pain, and bowel obstruction or female infertility. The mechanisms underlying adhesion formation remain unclear and thus, effective treatments are not forthcoming. Peritoneal macrophages accumulate after surgery and previous studies have attributed either pro- or anti-scarring properties to these cells. We propose that there are complex and nuanced responses after surgery with respect to both resident and also monocyte-derived peritoneal macrophage subpopulations. Moreover, we contend that differences in responses of specific macrophage subpopulations in part explain the risk of developing peritoneal scars. We ch

SUBMITTER: Sahputra R 

PROVIDER: S-EPMC9583908 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature