Identifying Mast Cells in Gastrointestinal Biopsies in Pediatric Irritable Bowel Patients.

ABSTRACT:

Objectives

Mast cells (MCs) have been proposed to be involved in the pathophysiology of irritable bowel syndrome (IBS). Nonetheless, the quantity and distribution of MCs in the gastrointestinal tract of pediatric patients with IBS are not well defined. This study aimed to compare the number of MCs in children with and without IBS and to establish histopathological reference values in pediatrics.

Methods

Forty-nine participants with IBS were prospectively enrolled and classified into IBS with atopy (n = 29) and IBS without atopy (n = 20). As our retrospective control group, we selected 42 individuals with a history of polyposis syndrome or gastroesophageal reflux disease with normal histopathology. Retrospective selection of the control cohort was performed in a manner simila

SUBMITTER: Rizvi SA 

PROVIDER: S-EPMC9584038 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature