Effects of stimulation area and temperature rates on offset analgesia.

ABSTRACT:

Introduction

Offset analgesia describes the effect of a slightly reduced nociceptive stimulus, resulting in a disproportionate large reduction in the pain perception. This effect may be associated with descending pain inhibition, but parameters influencing this phenomenon are poorly understood.

Objectives

In this study, 2 separate experiments were conducted to investigate both, the spatial aspects of offset analgesia and the influence of different rates of temperature rise.

Methods

In both experiments, 29 healthy participants received individualized and heat-based offset analgesia paradigms applied to the forearm, with continuous assessment of pain intensity. In experiment 1, offset analgesia paradigms with 3 different rates of temperature rise were applied, whereas i

SUBMITTER: Szikszay TM 

PROVIDER: S-EPMC9584187 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature