The Immune Signatures data resource, a compendium of systems vaccinology datasets.

ABSTRACT: Vaccines are among the most cost-effective public health interventions for preventing infection-induced morbidity and mortality, yet much remains to be learned regarding the mechanisms by which vaccines protect. Systems immunology combines traditional immunology with modern 'omic profiling techniques and computational modeling to promote rapid and transformative advances in vaccinology and vaccine discovery. The NIH/NIAID Human Immunology Project Consortium (HIPC) has leveraged systems immunology approaches to identify molecular signatures associated with the immunogenicity of many vaccines. However, comparative analyses have been limited by the distributed nature of some data, potential batch effects across studies, and the absence of multiple relevant studies from non-HIPC groups in ImmP

SUBMITTER: Diray-Arce J 

PROVIDER: S-EPMC9584267 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature