Challenges and costs of donor screening for fecal microbiota transplantations.

ABSTRACT:

Background

The increasing interest to perform and investigate the efficacy of fecal microbiota transplantation (FMT) has generated an urge for feasible donor screening. We report our experience with stool donor recruitment, screening, follow-up, and associated costs in the context of clinical FMT trials.

Methods

Potential stool donors, aged between 18-65 years, underwent a stepwise screening process starting with an extensive questionnaire followed by feces and blood investigations. When eligible, donors were rescreened for MDROs and SARS-CoV-2 every 60-days, and full rescreening every 4-6 months. The costs to find and retain a stool donor were calculated.

Results

From January 2018 to August 2021, 393 potential donors underwent prescreening, of which 202 (51.4%) did n

SUBMITTER: Benard MV 

PROVIDER: S-EPMC9584411 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature