The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells.

ABSTRACT:

Background

Multiple myeloma (MM) is an incurable malignancy of plasma cells. The serine protease matriptase is frequently dysregulated in human carcinomas, which facilitates tumor progression and metastatic dissemination. The importance of matriptase in hematological malignancies is yet to be clarified. In this study, we aimed to characterize the role of matriptase in MM.

Materials and methods

mRNA expression of matriptase and its inhibitors hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 was studied in primary MM cells from patient samples and human myeloma cell lines (HMCLs). We further investigated the effect of matriptase on migration and proliferation of myeloma cells in vitro. By use of the CoMMpass database, we assessed the clinical relevance of

SUBMITTER: Steiro I 

PROVIDER: S-EPMC9584456 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature