Cell shape anisotropy contributes to self-organized feather pattern fidelity in birds.

ABSTRACT: Developing tissues can self-organize into a variety of patterned structures through the stabilization of stochastic fluctuations in their molecular and cellular properties. While molecular factors and cell dynamics contributing to self-organization have been identified in vivo, events channeling self-organized systems such that they achieve stable pattern outcomes remain unknown. Here, we described natural variation in the fidelity of self-organized arrays formed by feather follicle precursors in bird embryos. By surveying skin cells prior to and during tissue self-organization and performing species-specific ex vivo drug treatments and mechanical stress tests, we demonstrated that pattern fidelity depends on the initial amplitude of cell anisotropy in regions of the developing dermis comp

SUBMITTER: Curantz C 

PROVIDER: S-EPMC9584522 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature