Capripoxviruses, leporipoxviruses, and orthopoxviruses: Occurrences of recombination.

ABSTRACT: Poxviruses are double-stranded DNA viruses with several members displaying restricted host ranges. They are genetically stable with low nucleotide mutation rates compared to other viruses, due to the poxviral high-fidelity DNA polymerase. Despite the low accumulation of mutations per replication cycle, poxvirus genomes can recombine with each other to generate genetically rearranged viruses through recombination, a process directly associated with replication and the aforementioned DNA polymerase. Orthopoxvirus replication is intimately tethered to high frequencies of homologous recombination between co-infecting viruses, duplicated sequences of the same virus, and plasmid DNA transfected into poxvirus-infected cells. Unfortunately, the effect of these genomic alterations on the cellular c

SUBMITTER: Sprygin A 

PROVIDER: S-EPMC9584655 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature