GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation.

ABSTRACT: γ-Aminobutyrate (GAB), the biochemical form of (GABA) γ-aminobutyric acid, participates in shaping physiological processes, including the immune response. How GAB metabolism is controlled to mediate such functions remains elusive. Here we show that GAB is one of the most abundant metabolites in CD4⁺ T helper 17 (T_H17) and induced T regulatory (iT_reg) cells. GAB functions as a bioenergetic and signalling gatekeeper by reciprocally controlling pro-inflammatory T_H17 cell and anti-inflammatory iT_reg cell differentiation through distinct mechanisms. 4-Aminobutyrate aminotransferase (ABAT) funnels GAB into the tricarboxylic acid (TCA) cycle to maximize carbon allocation in promoting T_H17 cell differentiation. By contrast, the abse

SUBMITTER: Kang S 

PROVIDER: S-EPMC9584824 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature