Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones.

ABSTRACT: Humans and animals are exposed to multiple substances in their food and feed that might have a negative health impact. Among these substances, the Fusarium mycoestrogen zearalenone (ZEN) and its metabolites α-zearalenol (α-ZEL) and α-zearalanol (α-ZAL) are known to possess endocrine disruptive properties. In a mixed diet or especially animal feed, these potential contaminants might be ingested together with naturally occurring phytoestrogens such as soy isoflavones. So far, risk assessment of potential endocrine disruptors is usually based on adverse effects of single compounds whereas studies investigating combinatorial effects are scarce. In the present study, we investigated the estrogenic potential of mycoestrogens and the isoflavones genistein (GEN), daidzein (DAI) and glycitein (GLY)

SUBMITTER: Grgic D 

PROVIDER: S-EPMC9584851 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature