Reduced renal elimination of larger molecules is a strong predictor for mortality.

ABSTRACT: Renal dysfunction is a major risk factor for premature death and has been studied extensively. A new renal syndrome, shrunken pore syndrome (SPS), confers higher mortality in all studied populations. SPS is a condition in which cystatin C-based estimation of glomerular filtration rate (eGFR_{cystatin C}) is ≥ 60% than creatinine-based estimation of glomerular filtration rate (eGFR_creatinine). We aimed to study the impact of SPS on mortality in a cohort of patients with follow up of up to 10 years. This was a retrospective single centre cohort study. We enrolled 3993 consecutive patients undergoing elective cardiac surgery. Outcome was evaluated using Kaplan Meier analysis and multivariable Cox regression. 1-, 5- and 10-year survival for patients with SPS was 90%, 59% and

SUBMITTER: Herou E 

PROVIDER: S-EPMC9584920 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature