Mitochondrial biogenesis, telomere length and cellular senescence in Parkinson's disease and Lewy body dementia.

ABSTRACT: Progressive age is the single major risk factor for neurodegenerative diseases. Cellular aging markers during Parkinson's disease (PD) have been implicated in previous studies, however the majority of studies have investigated the association of individual cellular aging hallmarks with PD but not jointly. Here, we have studied the association of PD with three aging hallmarks (telomere attrition, mitochondrial dysfunction, and cellular senescence) in blood and the brain tissue. Our results show that PD patients had 20% lower mitochondrial DNA copies but 26% longer telomeres in blood compared to controls. Moreover, telomere length in blood was positively correlated with medication (Levodopa Equivalent Daily Dose, LEDD) and disease duration. Similar results were found in brain tissue, where p

SUBMITTER: Asghar M 

PROVIDER: S-EPMC9584960 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature