Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism.

ABSTRACT: Metabolic disturbances in the brain are assumed to be early changes involved in the pathogenesis of depression, and these alterations may be intensified by a deficiency of thyroid hormones. In contrast to glucose metabolism, the link between altered brain lipids and the pathogenesis of depression is poorly understood, therefore in the present study, we determine transcription factors and enzymes regulating cholesterol and fatty acid biosynthesis in the brain structures in an animal model of depression, hypothyroidism and the coexistence of these diseases.In used model of depression, a decrease in the active form of the transcription factor SREBP-2 in the hippocampus was demonstrated, thus suggesting a reduction in cholesterol biosynthesis. In turn, in the hypothyroidism model, the reductio

SUBMITTER: Glombik K 

PROVIDER: S-EPMC9584974 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature