A systematic review of the efficacy and safety of anticoagulants in advanced chronic kidney disease.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) have an increased risk of venous thromboembolism (VTE) and atrial fibrillation (AF). Anticoagulants have not been studied in randomised controlled trials with CrCl < 30 ml/min. The objective of this review was to identify the impact of different anticoagulant strategies in patients with advanced CKD including dialysis.

Methods

We conducted a systematic review of randomized controlled trials and cohort studies, searching electronic databases from 1946 to 2022. Studies that evaluated both thrombotic and bleeding outcomes with anticoagulant use in CrCl < 50 ml/min were included.

Results

Our initial search yielded 14,503 papers with 53 suitable for inclusion. RCTs comparing direct oral anticoagulants (DOACs) versus war

SUBMITTER: Parker K 

PROVIDER: S-EPMC9584987 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature