Estimated GFR in autosomal dominant polycystic kidney disease: errors of an unpredictable method.

ABSTRACT:

Background

Autosomal dominant polycystic kidney disease (ADPKD) causes about 10% of cases of end stage renal disease. Disease progression rate is heterogeneous. Tolvaptan is presently the only specific therapeutic option to slow kidney function decline in adults at risk of rapidly progressing ADPKD with chronic kidney disease (CKD) stages 1-4. Thus, a reliable evaluation of kidney function in patients with ADPKD is needed.

Methods

We evaluated the agreement between measured (mGFR) and estimated glomerular filtration rate (eGFR) by 61 formulas based on creatinine and/or cystatin-C (eGFR) in 226 ADPKD patients with diverse GFR values, from predialysis to glomerular hyperfiltration. Also, we evaluated whether incorrect categorization of CKD using eGFR may interfere with the ind

SUBMITTER: Rodriguez RM 

PROVIDER: S-EPMC9584992 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature