Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma.

ABSTRACT:

Purpose

Growth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of growth hormone and insulin-like growth factor 1, causing increased morbidity and mortality. Previous studies have investigated the transcription of GHPA. However, the gene regulatory landscape has not been fully characterized. The objective of our study was to unravel the changes in chromatin accessibility and transcription in GHPA.

Methods

Six patients diagnosed with GHPA in the Department of Neurosurgery at Huashan Hospital were enrolled in our study. Primary pituitary adenoma tissues and adjacent normal pituitary specimens with no morphologic abnormalities from these six patients were obtained at surgery. RNA sequencing (RNA-seq) and assay for transposase-ac

SUBMITTER: Wang M 

PROVIDER: S-EPMC9584994 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature