Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis.

ABSTRACT:

Rationale

Delta-9-tetrahydrocannabinol (THC), an active component of cannabis, can cause anxiety in some users during intoxication. Cannabidiol (CBD), another constituent of cannabis, has anxiolytic properties suggesting that cannabis products containing CBD in addition to THC may produce less anxiety than THC-only products. Findings to date around this issue have been inconclusive and could conceivably depend on moderating factors such as baseline anxiety levels in users.

Objective

The present study examined whether anxiety following single doses of vaporised THC, CBD and THC/CBD might be explained by state and trait anxiety levels at baseline.

Methods

A placebo-controlled, randomised, within-subjects study including 26 healthy recreational cannabis users tested the

SUBMITTER: Hutten NRPW 

PROVIDER: S-EPMC9584997 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature