Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology.

ABSTRACT: The vast majority of excitatory synapses are formed on small dendritic protrusions termed dendritic spines. Dendritic spines vary in size and density that are crucial determinants of excitatory synaptic transmission. Aberrations in spine morphogenesis can compromise brain function and have been associated with neuropsychiatric disorders. Actin filaments (F-actin) are the major structural component of dendritic spines, and therefore, actin-binding proteins (ABP) that control F-actin dis-/assembly moved into the focus as critical regulators of brain function. Studies of the past decade identified the ABP cofilin1 as a key regulator of spine morphology, synaptic transmission, and behavior, and they emphasized the necessity for a tight control of cofilin1 to ensure proper brain function. Here,

SUBMITTER: Heinze A 

PROVIDER: S-EPMC9585016 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature