Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss.

ABSTRACT: This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT_MyoD) to injured tissue in vivo. TNT_MyoD was performed on skin and successfully induced expression of myogenic factors. TNT_MyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNT_MyoD is promising as VML intervention.

SUBMITTER: Clark A 

PROVIDER: S-EPMC9585072 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature