Postinjury platelet aggregation and venous thromboembolism.

ABSTRACT:

Background

Posttraumatic venous thromboembolism (VTE) remains prevalent in severely injured patients despite chemoprophylaxis. Importantly, although platelets are central to thrombosis, they are not routinely targeted in prevention of posttraumatic VTE. Furthermore, platelets from injured patients show ex vivo evidence of increased activation yet impaired aggregation, consistent with functional exhaustion. However, the relationship of this platelet functional phenotype with development of posttraumatic VTE is unknown. We hypothesized that, following injury, impaired ex vivo platelet aggregation (PA) is associated with the development of posttraumatic VTE.

Methods

We performed a secondary analysis of 133 severely injured patients from a prospective observational study investi

SUBMITTER: Matthay ZA 

PROVIDER: S-EPMC9585095 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature