Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences.

ABSTRACT: Adverse childhood experiences (ACEs, i.e., abuse, neglect, household dysfunction) represent a potential risk factor for a wide range of long-lasting diseases and shorter life expectancy. We recently described a 1-week residential group program, based on mindfulness training, artistic expression and EMDR group therapy, that significantly reduced PTSD-related symptoms and increased attention/awareness-related outcomes in adolescent girls with multiple ACEs in a randomized controlled study. Since epigenetic mechanisms (i.e., DNA methylation) have been associated with the long-lasting effects of ACEs, the present report extends these prior findings by exploring genome-wide DNA methylation changes following the program. Saliva samples from all participants (n = 44) were collected and genomic DN

SUBMITTER: Kaliman P 

PROVIDER: S-EPMC9585146 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature