Investigation of the biomarkers involved in ectopic ossification: The shared mechanism in ossification of the spinal ligament

ABSTRACT: Background: Ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) are multifactor diseases characterized by progressively ectopic ossification in the spinal ligament. However, the shared ossification mechanism of OPLL and OLF remains to be elucidated. The study aims to investigate the common biomarkers related to ectopic ossification and the potential molecular regulatory mechanism. Methods: Microarray and RNA-seq datasets were obtained from Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) from OPLL and OLF were identified to construct the protein-protein interaction (PPI) network. Furthermore, the hub intersection genes were screened and the diagnostic performance was assessed in the external OLF and OPL

SUBMITTER: Liu J 

PROVIDER: S-EPMC9585156 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature