Evolution of Mycobacterium tuberculosis drug resistance in the genomic era.

ABSTRACT: Mycobacterium tuberculosis has acquired drug resistance to all drugs that have been used against it, including those only recently introduced into clinical practice. Compared to other bacteria, it has a well conserved genome due to its role as an obligate human pathogen that has adapted to a niche over five to ten thousand years. These features facilitate reconstruction and dating of M. tuberculosis phylogenies, giving key insights into how resistance has been acquired and spread globally. Resistance to each new drug has occurred within five to ten years of clinical use and has occurred even more rapidly with recently introduced drugs. In most cases, resistance-conferring mutations come with a fitness cost, but this can be overcome by compensatory mutations which restore fitn

SUBMITTER: Nimmo C 

PROVIDER: S-EPMC9585206 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature