Identification of microsatellite instability and immune-related prognostic biomarkers in colon adenocarcinoma.

ABSTRACT:

Background

Colon adenocarcinoma (COAD) is a prevalent malignancy that causes significant mortality. Microsatellite instability plays a pivotal function in COAD development and immunotherapy resistance. However, the detailed underlying mechanism requires further investigation. Consequently, identifying molecular biomarkers with prognostic significance and revealing the role of MSI in COAD is important for addressing key obstacles in the available treatments.

Methods

CIBERSORT and ESTIMATE analyses were performed to evaluate immune infiltration in COAD samples, followed by correlation analysis for MSI and immune infiltration. Then, differentially expressed genes (DEGs) in MSI and microsatellite stability (MSS) samples were identified and subjected to weighted gene co-expressio

SUBMITTER: Sun Z 

PROVIDER: S-EPMC9585257 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature