GLDC mitigated by miR-30e regulates cell proliferation and tumor immune infiltration in TNBC.

ABSTRACT:

Background

TNBC, whose clinical prognosis is poorer than other subgroups of breast cancer, is a malignant tumor characterized by lack of estrogen receptors, progesterone hormone receptors, and HER2 overexpression. Due to the lack of specific targeted drugs, it is crucial to identify critical factors involved in regulating the progression of TNBC.

Methods

We analyzed the expression profiles of TNBC in TCGA and the prognoses values of GLDC. Correlations of GLDC and tumor immune infiltration were also identified. CCK8 and BrdU incorporation assays were utilized to determine cell proliferation. The mRNA and protein levels were examined by using Real-time PCR and Western blot analysis.

Results

In the present study, we analyzed the mRNA expression profiles of TNBC in TCGA a

SUBMITTER: Xie H 

PROVIDER: S-EPMC9585280 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature