The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease.

ABSTRACT: Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that fall into two main categories: Crohn's disease (CD) and ulcerative colitis (UC). The gastrointestinal tract extends from the mouth to the anus and harbors diverse bacterial communities. Several sequencing-based studies have identified an intestinal enrichment of oral-associated bacteria and demonstrated their ability to induce intestinal inflammation in mice, suggesting that intestinal pathobionts originate from the oral cavity, particularly members of the genus Streptococcus. This study aimed to investigate the composition of the salivary and fecal microbiome of IBD patients (n = 14) compared to healthy controls (n = 12) and to determine the abundance of common bacterial taxa in both niches. Metageno

SUBMITTER: Abdelbary MMH 

PROVIDER: S-EPMC9585322 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature