Identification and characterization of extracellular vesicles from red cells infected with Babesia divergens and Babesia microti.

ABSTRACT: Babesiosis is a zoonosis and an important blood-borne human parasitic infection that has gained attention because of its growing infection rate in humans by transfer from animal reservoirs. Babesia represents a potential threat to the blood supply because asymptomatic infections in man are common, and blood from such donors can cause severe disease in certain recipients. Extracellular vesicles (EVs) are vesicles released by cells that contain a complex mixture of proteins, lipids, glycans, and genetic information that have been shown to play important roles in disease pathogenesis and susceptibility, as well as cell-cell communication and immune responses. In this article, we report on the identification and characterization of EVs released from red blood cells (RBCs) infected by tw

SUBMITTER: Beri D 

PROVIDER: S-EPMC9585353 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature