Concise two-step chemical synthesis of molnupiravir† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2ra05064a

ABSTRACT: A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%. Fast, effective and chromatography column-free chemical synthesis of molnupiravir.

SUBMITTER: Pereira V 

PROVIDER: S-EPMC9585438 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature