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Concise two-step chemical synthesis of molnupiravir.

ABSTRACT: A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%.

SUBMITTER: Pereira VRD

PROVIDER: S-EPMC9585438 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Concise two-step chemical synthesis of molnupiravir.

Pereira Vinícius R D VRD Bezerra Marco A M MAM Gomez Mauro R B P MRBP Martins Guilherme M GM da Silva Adilson D AD de Oliveira Kleber T KT de Souza Rodrigo O M A ROMA Amarante Giovanni W GW

RSC advances 20221021 46

A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%. ...[more]

PMID: 36329948

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