Ontology highlight
ABSTRACT:
SUBMITTER: Lee A
PROVIDER: S-EPMC9585528 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Lee Aaron A Sousa de Almeida Mauro M Milinkovic Daela D Septiadi Dedy D Taladriz-Blanco Patricia P Loussert-Fonta Céline C Balog Sandor S Bazzoni Amelie A Rothen-Rutishauser Barbara B Petri-Fink Alke A
Nanoscale 20221021 40
Cells continuously exert forces on their environment and respond to changes in mechanical forces by altering their behaviour. Many pathologies such as cancer and fibrosis are hallmarked by dysregulation in the extracellular matrix, driving aberrant behaviour through mechanotransduction pathways. We demonstrate that substrate stiffness can be used to regulate cellular endocytosis of particles in a size-dependent fashion. Culture of A549 epithelial cells and J774A.1 macrophages on polystyrene/glas ...[more]