Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis.

ABSTRACT: Rhinovirus (RV), which is associated with acute exacerbations, also causes persistent lung inflammation in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are not well-known. Recently, we demonstrated that RV causes persistent lung inflammation with accumulation of a subset of macrophages (CD11b⁺/CD11c⁺), and CD8⁺ T cells, and progression of emphysema. In the present study, we examined the mechanisms underlying the RV-induced persistent inflammation and progression of emphysema in mice with COPD phenotype. Our results demonstrate that at 14 days post-RV infection, in addition to sustained increase in CCL3, CXCL-10 and IFN-γ expression as previously observed, levels of interleukin-33 (IL-33), a ligand for ST2 recepto

SUBMITTER: Gimenes JA 

PROVIDER: S-EPMC9585538 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature