Quantitative spinal cord MRI and sexual dysfunction in multiple sclerosis

ABSTRACT:

Background

Sexual dysfunction (SD) is frequently reported in multiple sclerosis (MS) and is likely related to MS-related damage to the spinal cord (SC).

Objective

To assess associations between SD and quantitative MRI measures in people with MS (pwMS).

Methods

This pilot study included 17 pwMS with SD who completed questionnaires assessing SD, mood, and fatigue. All participants underwent brain, cervical, and thoracic SC-MRI at 3T. Quantitative brain and SC-MRI measures, including brain/SC atrophy, SC lesion count, diffusion-tensor imaging (DTI) indices (fractional anisotropy [FA], mean, perpendicular, parallel diffusivity [MD, λ⊥, λ||]) and magnetization-transfer ratio (MTR) were obtained. Associations between quantitative MRI measures and SD were assessed while

SUBMITTER:  

PROVIDER: S-EPMC9585573 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature