Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition.

ABSTRACT:

Background

Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hypertension during pregnancy has been associated with impaired placental functions and with an increased risk for children to suffer from cardiovascular and respiratory diseases later on. Investigating changes in placental DNA methylation levels and cell-type composition in association with maternal blood pressure could help elucidate its relationships with placental and fetal development.

Methods

Taking advantage of a large cohort of 666 participants, we investigated the association between epigenome-wide DNA methylation patterns in the placenta, measured using

SUBMITTER: Broseus L 

PROVIDER: S-EPMC9585724 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature